Cannanda CB2™ Salve 15mL

Activating the CB2 Receptor

CB2 is one of the two main receptors of the ECS. There are numerous benefits to activating this receptor without activating the CB1 receptor (the receptor responsible for the “high” associated with some plant based medicines). The following is a small list of studies illustrating the benefits of CB2 activation.

Pain & Inflammation:

• The CB2 receptor and its role as a regulator of inflammation (Cell Mol Life Sci. 2016; 73(23): 4449-70.)
• Targeting CB2 receptors and the endocannabinoid system for the treatment of pain (Brain Res Rev. 2009 Apr; 60(1): 255-266.)
• Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain (Br J Pharmacol. 2008 Jan; 153(2): 319–334.)
• The central cannabinoid receptor type-2 (CB2) and chronic pain. (Int J Neurosci. 2017 Sep;127(9):812-823.)

Osteoarthritis:

• Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint (PLoS One. 2013; 8(11): e80440.)
• Expression of cannabinoid receptors in human osteoarthritic cartilage: Implications for future therapies (Cannabis Cannabinoid Res. 2016 Jan 1;1(1):3-15)

Rheumatoid arthritis:

• CB2 as a potential therapeutic target in rheumatoid arthritis (Musculoskeletal Disorders. 2014; 15: 275.)
• CB2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis (Rheumatology. 2014; 53(5): 802-809.)
• Role of CB2 in mediating inflammation in rheumatoid arthritis synovial fibroblasts. (Clin Exp Rheumatol. 2019 Nov-Dec;37(6):1026-1035.)

Migraine:

• Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model (J Headache Pain. 2014; 15(1): 14.)

Skin Health:

CB2 exerts antifibrotic effects in experimental dermal fibrosis. (Arthritis Rheum. 2009 Apr;60(4):1129-36.)

Enhance your CBD Experience™

As mentioned, CB2™ can greatly enhance the benefits you already receive from other products. Here’s how:

• Activating CB2 receptors is not how other plant medicine oils are thought to work. This is because they only have a very weak ability to bind to CB2 receptors.
• Newer studies suggest plant medicine oils may influence cannabinoid receptor shape and/or inhibit the proteins that remove our endocannabinoids. This means our own endocannabinoids can then activate CB2 receptors, and could be how we get the benefits from other products.

However, if we can supply the body with external sources of compounds that directly activate CB2 receptors (such as those found in our CB2™ blends, we can amplify those benefits. It’s actually the perfect combination!

Ingredients
Organic shea butter, Cannanda CB2™ terpene blend (100% natural terpenes extracted from botanical sources), organic peppermint essential oil, organic hemp seed oil, organic carnauba wax.

Contains NO: animal by-products, wheat/gluten, dairy/lactose, soy, corn, sugar, GMO, artificial flavours or colours.

Suggested Uses:
Massage into skin as needed for local relief. For external use only. Keep away from mucous membranes. For higher potency, add drops of CB2™ Wellness terpene blend to the area as you massage the salve into you skin.

How to mix with CBD or cannabis oils: With cap on tightly, place entire tin in a cup of hot water for 5-10 minutes (not boiling water, hot water from your tap is sufficient). Carefully remove tin from water and place on a level surface. Unscrew cap and add CBD or cannabis oil (be careful not to overfill). Using a toothpick, gently stir the CBD/cannabis oil into the liquified salve. Once thoroughly mixed together, screw cap back on and place in fridge until solidified.